Discovery Labs Receives $1.9 Million Fast Track SBIR Grant from the National Institutes of Health (NIH) to Support AEROSURF® Phase 2a Clinical Study
Warrington, PA, June 17, 2014 — Discovery Laboratories, Inc. (NASDAQ: DSCO) today announced that it has been awarded the final $1.9 million of a $2.4 million Fast Track Small Business Innovation Research (SBIR) Grant from the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH). This award will provide support for the ongoing phase 2a clinical trial for AEROSURF®, Discovery Labs’ investigational combination drug/device product. AEROSURF is in development to provide KL4 surfactant therapy through nasal continuous positive airway pressure (nCPAP) for respiratory distress syndrome (RDS) in premature infants. Discovery Labs was notified in 2010 that it was eligible for consideration under this grant program, and previously received $580,000 to support development activities related to its capillary aerosol generator technology. The company expects to utilize the $1.9 million during 2014.
Strabismus Risk Much Higher in Very Low Birth Weight Infants
The risk for strabismus was 14 times higher in very premature infants who weighed less than 2000 g at birth, independent of gestational age.
Ob-Gyn Guidance Issued for Young Cancer Patient Concerns (CME)
Cancer and its treatment may have an immediate or delayed impact on reproductive health
More U.S. teens' report using human growth hormone, group says
U.S. teenagers' reported use of synthetic human growth hormone more than doubled between 2012 to 2013 as they sought to improve athletic performance and appearance, a survey by anti-drug advocates found.
Many Obese U.S. Kids Think They're Thinner Than They Are
Many obese and overweight American children and teens look in the mirror and tell themselves their weight is fine, U.S. health officials reported.
Keeping Febrile Infants in Hospital for More Than 24 Hours Unnecessary: Researchers
In febrile but otherwise healthy infants up to three months old with bacteremia, blood cultures will grow pathogenic bacteria within 24 hours of collection, a new study shows.
Injuries on the Increase in High School Lacrosse, Study Shows
More than 22 percent of injuries are concussions, researchers call for better player protections
Peer Mentoring Helps Moms of Developmentally Disabled Kids
Moms of children with neurodevelopmental disabilities benefit from cognitive behavioral interventions delivered by peer mentors.
Heavy Preschoolers, Parents Treated Together Can Lower BMIs
However, the intervention may present a time challenge for pediatricians and unrealistic expectations for parents, a child obesity expert has noted.
Poor teens may get more than academics at top schools; less risky health behaviors seen, too
Disadvantaged teens may get more than an academic boost by attending top-notch high schools - their health may also benefit, a study suggests.
Rates of abdominal obesity leveling off among kids
After rising steadily for more than 10 years, the proportion of U.S. kids defined as obese due to a large waist circumference held steady between 2003 and 2012.
Common gene variants account for most genetic risk for autism
Roles of heritability, mutations, environment estimated - NIH-funded study
Screening Aid Helps Identify Children With Developmental Delay Earlier
Using a computerized decision aid to help automate developmental surveillance and screening (DSS) at well-child visits results in more children being screened and earlier diagnoses for those with developmental delay.
Poor Parent-Provider Agreement in Advanced Pediatric Cancer (CME)
Poor concordance regarding prognosis and goals of care; variation seen by cancer type
Many Sexually Active U.S. Teens Not Tested for HIV: CDC
Only one in five sexually active U.S. teens has been tested for HIV, a new government report shows.
Cord Clamping Timing Affects Neonatal Outcome
Delay in cord clamping after spontaneous respiration decreases risk of death/admission
'Little League Shoulder' on the Rise
Rest, possibly combined with physical therapy, key to recovery, research suggests
NIH scientists identify gene linked to fatal inflammatory disease in children
Repurposed drugs may offer first potential therapy
Asthma medication linked to growth suppression in children
A review of past studies has found that inhaled corticosteroids used to treat asthma could result in restricting the growth of children who have the condition.
Could the cause of cerebral palsy run in the family?
A study published by a research team from Norway has found that babies born into families in which someone has cerebral palsy are more likely to develop the condition themselves.
Amblyopia Tx at Young Age Results in Good Vision Later
Outcomes are similar regardless of initial treatment with atropine or patching
Common Treatment Doesn't Help Infants With Congenital Diaphragmatic Hernia
Inhaled nitric oxide is widely used in infants with congenital diaphragmatic hernia (CDH), but there's no evidence that it significantly improves outcomes, according to a database study.
iPads Can Trigger Nickel Allergies in Kids
When an 11-year-old boy in San Diego developed a nasty skin allergy, doctors traced it to the nickel in his family's iPad.
Ultrasonography Accurately Diagnoses Hand Bony Fractures in Children
Ultrasonography diagnoses hand bony fractures in pediatric patients with greater than 90% accuracy, researchers from Italy report.
Spoonfuls don't help the medicine go down safely: They can lead to dosing mistakes, study says
The song says a spoonful of sugar helps the medicine go down, but a study says that kind of imprecise measurement can lead to potentially dangerous dosing mistakes.
For sleep-related infant deaths, bed-sharing is greatest risk factor
Parents should think twice before sharing their bed with an infant; a new study suggests bed-sharing is the leading cause of sleep-related deaths in younger infants.
Teens, ATVs a Dangerous Combo
Iowa study found three-quarters of kids drove the off-road vehicles, more than half were in accidents
Delaying Kid's Knee Surgery Could Be a Bad Play, Study Finds
Secondary injuries more common among children who postpone ligament repair, research shows
Emergency Surgeries on Weekends Riskier for Kids: Study
Possible explanations include fewer hospital staffers, slower response times, researchers say
Postop Tympanostomy Tube Obstruction Common
More than 10% of children undergoing tympanostomy had postoperative tube obstruction, with serous fluid and increased time to follow-up visit predicting tube occlusion.
Preterm newborns '30-50% more likely to survive in busy neonatal centers'
In the UK, specialist neonatal units that treat a large volume of infants were found to have much greater survival rates than less busy units, a new study published in BMJ Open reports. Specifically, the research found that the chances of survival were 30% higher for babies born prematurely after 27-32 weeks of pregnancy, and 50% higher for babies born after less than 27 weeks of pregnancy.
Late Referral for About One in Four Neonates With Critical CHD
A considerable proportion of neonates with critical congenital heart disease (CCHD) are not referred to a cardiac center by age 4 days, according to a study published online June 30 in Pediatrics. David E. Fixler, M.D., from the University of Texas Southwestern Medical Center in Dallas, and colleagues describe the correlation between timing of referral to a cardiac center and mortality in 2,360 neonates with CCHD, born before pulse oximetry screening (1996 to 2007).
Cesarean section may cause epigenetic changes
A new study from Karolinska Institute indicates that the mode of delivery could make an imprint in the stem cells of the newborn infant. The finding may be of interest for understanding why individuals born by cesarean section statistically have an increased risk of immunological diseases. However, it is still unclear if this so-called epigenetic mechanism is temporary or remains over time.
Deaths of four premature babies and burns in dozens more linked to antiseptic, says regulator
The deaths of four premature babies and serious burns in dozens more have been linked to an antiseptic solution, the medicines regulator has warned, urging doctors to use it sparingly. Doctors use chlorhexidine solution to clean the skin of premature babies before tubes are inserted for feeding and medicines but it has been found to cause serious chemical burns when used carelessly.
The preemie brain moves in its own way
Movement impairments can be among the most disabling of all problems that affect people born prematurely. Up to one third of all children born very preterm have noticeable movement problems. These problems range from simple clumsiness to more disabling conditions such as cerebral palsy. It has recently been suggested that movement problems may cause preemies to do worse on academic and cognitive tests.
Study proves telemedicine's value in preemie eye exams
A new study has determined that telemedicine can be used successfully to identify newborn infants who need specialized medical treatment for retinopathy or prematurity (ROP), a leading cause of treatable blindness. The study, conducted at 13 neonatal intensive care units in the United States and Canada and recently published in JAMA Ophthalmology, found that trained non-physician evaluators at a remote reading center could identify newborns at risk of acquiring ROP by studying retinal images transmitted to their computer screens.
Prepregnancy Obesity Linked to Earliest Preterm Births
Obese women who become pregnant are more likely to deliver before 28 weeks of pregnancy?, but the association between prepregnancy body mass index (BMI) and risk for preterm birth is complex and affected by race/ethnicity, gestational age, and parity, according to findings of a population-based cohort study published in the July issue of Paediatric and Perinatal Epidemiology.
Surgery may boost risks for smallest infants
Very-low-birth-weight (VLBW) babies who undergo major surgery appear to have an increased risk of death or subsequent neurodevelopmental impairment, according to a new study published June 16 in the journal JAMA Pediatrics. Major surgeries are procedures that require general anesthesia, and some animal studies have suggested that general anesthesia can increase the risk for neurocognitive or behavioral deficits.
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Heart rate variability may predict risk of disease in premature infants
Measuring variability of heart rate may identify premature infants at risk of developing necrotizing enterocolitis, a serious inflammatory condition that can lead to death, according to Penn State College of Medicine researchers. Necrotizing enterocolitis, or NEC, may lead to destruction of the intestinal wall and vital organ failure. It affects 6 to 10 percent of premature infants within the first two weeks of life.
Preterm infants have higher risk for RSV
Preterm infants who did not receive respiratory syncytial virus prophylaxis were three times more likely to be hospitalized for RSV than infants of the general population. Additional risk factors for RSV infection included daycare attendance or having siblings who attended daycare, according to study findings in The Pediatric Infectious Disease Journal.