Top News Headlines - Monday, December 22, 2014

Warrington, PA, June 17, 2014 — Discovery Laboratories, Inc. (NASDAQ: DSCO) today announced that it has been awarded the final $1.9 million of a $2.4 million Fast Track Small Business Innovation Research (SBIR) Grant from the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health (NIH). This award will provide support for the ongoing phase 2a clinical trial for AEROSURF®, Discovery Labs’ investigational combination drug/device product. AEROSURF is in development to provide KL4 surfactant therapy through nasal continuous positive airway pressure (nCPAP) for respiratory distress syndrome (RDS) in premature infants. Discovery Labs was notified in 2010 that it was eligible for consideration under this grant program, and previously received $580,000 to support development activities related to its capillary aerosol generator technology. The company expects to utilize the $1.9 million during 2014.

Sophisticated brain scans show the two conditions are somewhat similar, but are also markedly different

Parents look to the pediatrician or family doctor for information but don't want a recommendation

New online resources aim to help ease the transfer from pediatric to adult care for patients with diabetes or human growth hormone deficiency and for clinicians who are treating them.

Girls-only vaccination program leaves men at risk, especially those who have sex with men

Excellent outcomes for transplants from matched siblings, other donors if given before infection onset

Babies born with so-called "bubble boy" disease can often be cured with a stem cell transplant, regardless of the donor -- but early treatment is critical.

A simple blood test could help prevent neural tube birth defects such as spina bifida, new research finds.

Palivizumab prophylaxis for respiratory syncytial virus should be limited to at-risk infants and young children, according to an updated policy statement from the American Academy of Pediatrics (AAP).

Increased risk seen in infancy, early childhood, young adulthood; risks persist after adjustment

A new tool that takes less than 10 seconds to complete can effectively triage adolescents based on their risk of substance use disorder (SUD).

Tonsillectomies are commonly done to relieve sleep apnea in children, but a new study confirms that the treatment can speed kids' weight gain -- especially if they're already overweight.

Teenagers are more likely to discuss topics like sexual health and drug use with their doctors if their parents are out of the room for at least part of their check-up.

Oncologist and gynecologist should collaborate to provide appropriate treatment

Infants and children who are at risk of contracting meningitis because of specific health problems should be vaccinated against the infection, according to updated recommendations from the largest pediatrician group in the United States.

Glycated hemoglobin in fetal cord blood may be an accurate marker of in utero exposure to hyperglycemia, say researchers from Canada.

Babies at high risk for HIV should be started on antiretrovirals to reduce the disease to undetectable levels and potentially induce long-term viral remission.

Among infants managed for neonatal abstinence syndrome (NAS), strict weaning protocols were associated with significantly shorter opioid treatment duration and hospital stay compared to those treated without strict weaning parameters.

Parents of overweight and obese kids may want to help their kids be healthier, but they're more often willing to make changes in children's diets than in their activity levels.

A large international study finds that the age at which girls reach puberty - marked by the timing of their first menstrual period - is decided by a small subset of genes they inherit from one parent.

The risk for strabismus was 14 times higher in very premature infants who weighed less than 2000 g at birth, independent of gestational age.

Summer is here, and with it, hordes of teen and preteen athletes presenting for preparticipation exams (PPEs).

Cancer and its treatment may have an immediate or delayed impact on reproductive health

U.S. teenagers' reported use of synthetic human growth hormone more than doubled between 2012 to 2013 as they sought to improve athletic performance and appearance, a survey by anti-drug advocates found.

Many obese and overweight American children and teens look in the mirror and tell themselves their weight is fine, U.S. health officials reported.

In febrile but otherwise healthy infants up to three months old with bacteremia, blood cultures will grow pathogenic bacteria within 24 hours of collection, a new study shows.

More than 22 percent of injuries are concussions, researchers call for better player protections

Moms of children with neurodevelopmental disabilities benefit from cognitive behavioral interventions delivered by peer mentors.

However, the intervention may present a time challenge for pediatricians and unrealistic expectations for parents, a child obesity expert has noted.

Disadvantaged teens may get more than an academic boost by attending top-notch high schools - their health may also benefit, a study suggests.

After rising steadily for more than 10 years, the proportion of U.S. kids defined as obese due to a large waist circumference held steady between 2003 and 2012.

Roles of heritability, mutations, environment estimated - NIH-funded study

Using a computerized decision aid to help automate developmental surveillance and screening (DSS) at well-child visits results in more children being screened and earlier diagnoses for those with developmental delay.

Poor concordance regarding prognosis and goals of care; variation seen by cancer type

Only one in five sexually active U.S. teens has been tested for HIV, a new government report shows.

Delay in cord clamping after spontaneous respiration decreases risk of death/admission

The presence of serous fluid, and delayed follow-up after placement, are associated with an increased risk of postoperative tympanostomy tube obstruction, according to a retrospective medical record review.

In the UK, specialist neonatal units that treat a large volume of infants were found to have much greater survival rates than less busy units, a new study published in BMJ Open reports. Specifically, the research found that the chances of survival were 30% higher for babies born prematurely after 27-32 weeks of pregnancy, and 50% higher for babies born after less than 27 weeks of pregnancy.

A considerable proportion of neonates with critical congenital heart disease (CCHD) are not referred to a cardiac center by age 4 days, according to a study published online June 30 in Pediatrics. David E. Fixler, M.D., from the University of Texas Southwestern Medical Center in Dallas, and colleagues describe the correlation between timing of referral to a cardiac center and mortality in 2,360 neonates with CCHD, born before pulse oximetry screening (1996 to 2007).

A new study from Karolinska Institute indicates that the mode of delivery could make an imprint in the stem cells of the newborn infant. The finding may be of interest for understanding why individuals born by cesarean section statistically have an increased risk of immunological diseases. However, it is still unclear if this so-called epigenetic mechanism is temporary or remains over time.

The deaths of four premature babies and serious burns in dozens more have been linked to an antiseptic solution, the medicines regulator has warned, urging doctors to use it sparingly. Doctors use chlorhexidine solution to clean the skin of premature babies before tubes are inserted for feeding and medicines but it has been found to cause serious chemical burns when used carelessly.

Movement impairments can be among the most disabling of all problems that affect people born prematurely. Up to one third of all children born very preterm have noticeable movement problems. These problems range from simple clumsiness to more disabling conditions such as cerebral palsy. It has recently been suggested that movement problems may cause preemies to do worse on academic and cognitive tests.

A new study has determined that telemedicine can be used successfully to identify newborn infants who need specialized medical treatment for retinopathy or prematurity (ROP), a leading cause of treatable blindness. The study, conducted at 13 neonatal intensive care units in the United States and Canada and recently published in JAMA Ophthalmology, found that trained non-physician evaluators at a remote reading center could identify newborns at risk of acquiring ROP by studying retinal images transmitted to their computer screens.

Obese women who become pregnant are more likely to deliver before 28 weeks of pregnancy?, but the association between prepregnancy body mass index (BMI) and risk for preterm birth is complex and affected by race/ethnicity, gestational age, and parity, according to findings of a population-based cohort study published in the July issue of Paediatric and Perinatal Epidemiology.

Very-low-birth-weight (VLBW) babies who undergo major surgery appear to have an increased risk of death or subsequent neurodevelopmental impairment, according to a new study published June 16 in the journal JAMA Pediatrics. Major surgeries are procedures that require general anesthesia, and some animal studies have suggested that general anesthesia can increase the risk for neurocognitive or behavioral deficits.

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Measuring variability of heart rate may identify premature infants at risk of developing necrotizing enterocolitis, a serious inflammatory condition that can lead to death, according to Penn State College of Medicine researchers. Necrotizing enterocolitis, or NEC, may lead to destruction of the intestinal wall and vital organ failure. It affects 6 to 10 percent of premature infants within the first two weeks of life.

Preterm infants who did not receive respiratory syncytial virus prophylaxis were three times more likely to be hospitalized for RSV than infants of the general population. Additional risk factors for RSV infection included daycare attendance or having siblings who attended daycare, according to study findings in The Pediatric Infectious Disease Journal.

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